Granzyme B -mediated release of mitochondrial cell death factors are required for the activation of caspase-3. Furthermore, the degradation of granzyme B is known to decrease the susceptibility of cancer cells to NK-cell-mediated lysis during hypoxia. Granzyme B activity assays can be used for studying T cell immunity, CTL responses, cell …
of granzyme B is known to decrease the susceptibility of cancer cells to NK-cell-mediated lysis during hypoxia.2 Granzyme B activity assays can be used for studying T cell immunity, CTL responses, cell-mediated cytotoxicity, and apoptosis. The Granzyme B Activity Assay Kit provides a rapid, reliable, and sensitive procedure for measuring, 4/25/2013 · This Assay Kit is rapid, reliable and sensitive and can detect Granzyme B activity in various biological samples. Notes Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme -2 is a serine protease stored in the granules.
In BioVision’s Granzyme B Activity Assay Kit , active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500 nm. This Assay Kit is rapid, reliable and sensitive and can detect Granzyme B activity in various biological samples.
